GABAergic Neurons
From NeuroLex
A list of all neurons that have been indicated as using the neurotransmitter "GABA".
- This table is generated programmatically from the property "neurotransmitter" assigned to members of the Neuron class. To add to this list, go to the category page for the type of neuron you are interested in adding and add "GABA" to the "Has Neurotransmitter" field in the Petilla form.
This table is also available in CSV
| Neurotransmitter | Synonym | Definition | Located in | Species | |
|---|---|---|---|---|---|
| Amygdaloid nucleus paracapsular intercalated cell | GABA | GABA containing interneuron that occur in densely packed clusters located in and around the border of the basolateral amygdaloid nucleus and the external capsule. These cells are characterized by a small soma and a poorly developed short dendrite and their occurrence in tightly packed groups. Two distinct subtypes have been proposed by Marowsky et al (Neuron 48:1025, 2005) based on location and morphology. | Intercalated amygdaloid nuclei | ||
| Caudate nucleus matrix medium spiny cell | GABA | Striatal matrix spiny neuron that is located in the matrix compartment of the caudate nucleus | Matrix compartment of caudate nucleus | ||
| Cerebellum Golgi cell | GABA | Cerebellar Golgi neuron Cerebellar golgi cell |
Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell enters ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004. | Granular layer of cerebellar cortex | Vertebrata |
| Cerebellum Lugaro cell | GABA | Type of neuron found in cerebellar granule cell layer characterized by a fusiform cell body with thick, horizontally oriented dendrites. Lugaro cells are located in or slightly below the Purkinje cell layer outermost edge of the granular layer. | Purkinje cell layer of cerebellar cortex Granular layer of cerebellar cortex |
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| Cerebellum Purkinje cell | GABA | Purkinje neuron Purkinje's corpuscles Cerebellar Purkinje neuron |
Principal neuron (projection neuron) of the cerebellar cortex; cell bodies arranged in a single layer; characterized by a pear-shaped cell body, 1 (rarely 2) primary dendrites and an elaborate dendritic tree heavily invested with dendritic spines. | Purkinje cell layer of cerebellar cortex | Vertebrata |
| Cerebellum basket cell | GABA | Cerebellar basket cell | Intrinsic cell residing in the inner third of the molecular layer of the cerebellar cortex. Axons extend laterally, transverse to the folium, and densely innervate the somata of Purkinje neurons. Axon collaterals of the basket cell axon form the specialized terminal plexus, the "pinceau", around the Purkinje cell axon initial segment. Llinas, Walton and Lang. In: The Synaptic Organization of the Brain. 5th ed. 2004. | Molecular layer of cerebellar cortex | Vertebrata |
| Cerebellum stellate cell | GABA | Cerebellar stellate neuron Cerebellar stellate cell |
Multipolar neuron found in cerebellar molecular layer. | Molecular layer of cerebellar cortex | |
| Cochlear nucleus (dorsal) cartwheel cell | Glycine GABA |
Cartwheel neuron | The cell body lies in the pyramidal cell layer, and the dendrites span the molecular layer and are densely covered with spines, which are contacted by parallel fibers of the granule cells. Many features are shared with cerebellar Purkinje neurons. Cartwheel cells stain for GABA and glycine markers, and contact pyramidal, giant and other cartwheel cells through glycinergic synapses. | Molecular layer of dorsal cochlear nucleus | Mammal |
| Cochlear nucleus (dorsal) gabaergic cell | GABA | deep cerebellar nucleus GABAergic cell DCN Gabaergic cell Dorsal cochlear nucleus gabaergic cell |
Cochlear nuclear complex | ||
| Dentate gyrus HICAP cell | GABA | "The Dentate gyrus HICAP cells (HIlar Commissural-Associational pathway related cells) are multipolar or triangular cells in the polymorphic layer with thin, aspiny dendrites that extend both within the hilus and within the molecular layer. the axons of these HICAP cells extend through the granule cell layer and branch profusely in the inner third of the molecular layer." | |||
| Dentate gyrus HIPP cell | GABA | "The Dentate gyrus HIPP cell (HIlar Perforant Path-associated cell) is an interneuron in the Hippocampal formation. It is a long-spined multipolar cell that is conspicuous of distribution of copious, long and often branched spines over its cell body and dendrites. The axonal plexus can extend as much as 3.5mm along the septotemporal axis of the dentate gyrus. Since inhibitory interneurons typically have aspiny dendrites and relatively local axonal plexuses, this long spined multipolar/HIPP cell is a very atypical interneuron". | Hilus of dentate gyrus | ||
| Dentate gyrus IS-I cell | GABA | DG Interneuron-specific cell | The IS (Interneuron-Specific) subpopulation of interneurons have axons that exclusively innervate other interneurons. The Dentate gyrus IS-I class interneurons are visualized by immunostaining for Calretinin (CR) and establish multiple symmetrical synapses on the dendrites and somata of other CR-positive IS-I cells, Calbindin (CB) containing interneurons, and VIP-positive basket cells, but they do not innervate PV-containing interneurons. The dendrites of Dentate gyrus IS I neurons appear in all layers of Dentate gyrus and more characteristic feature of these dendrites is that they form long dendrodendritic junctions with each other. | Dentate gyrus molecular layer | |
| Dentate gyrus IS-II cell | GABA | DG Interneruon-specific II cell | The IS (Interneuron-Specific) subpopulation of interneurons have axons that exclusively innervate other interneurons. The Dentate Gyrus IS-II class interneurons are visualized by immunostaining for Vasoactive Intestinal Polypeptide (VIP). The dendrites of Dentate gyrus IS-II cells are present in all layers of Dentate gyrus. | Dentate gyrus molecular layer | |
| Dentate gyrus IS-III cell | GABA | The Dentate Gyrus MOPP cell (molecular layer perforant path-associated cell) is a interneuron in hippocampal formation. It is located deep in the DG molecular layer, has a multipolar or triangular cell body and gives rise to an axon that produces a substantial terminal plexus largely limited to the outer two thirds of the DG molecular layer. | Inner third of Dentate gyrus molecular layer Dentate gyrus molecular layer |
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| Dentate gyrus MOPP cell | GABA | The Dentate Gyrus MOPP cell (molecular layer perforant path-associated cell) is a interneuron in hippocampal formation. It is located deep in the DG molecular layer, has a multipolar or triangular cell body and gives rise to an axon that produces a substantial terminal plexus largely limited to the outer two thirds of the DG molecular layer. | Inner third of Dentate gyrus molecular layer Dentate gyrus molecular layer |
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| Dentate gyrus hilar cell | GABA | Hilus of dentate gyrus | |||
| Dentate gyrus spiny CR cell | GABA | DG Spiny CR immunoreactive cell DG Spiny CR-positive interneurons |
The DG spiny CR cells are present mostly in regions where mossy fibers have a high density, i.e., in the hilus of the dentate gyrus and in stratum lucidum of CA3 subfield. The dendrites and somata frequently possess numerous long hair-like spines that penetrate into bundles of mossy fibers. | Hilus of dentate gyrus | |
| Dentate gyrus trilaminar interneuron | GABA | Neuron with soma in the hilar region of the dentate gyrus. The dendritic arbor orientation and axon collateral distribution of this neuron resembles most the trilaminar neuron 0f CA1 region. The axon collaterals extend logitudinally into strata radiatum, pyramidale and oriens, some axon collaterals reaching the subiculum and a main branch entering the fimbria. The dendrites of these neurons run parallel with the pyramidal cell layer. Another special feature is these cells are calbindin-positive immunoreactive neurons. | Hilus of dentate gyrus CA3 alveus CA3 stratum oriens Border of CA3c region and hilus proper |
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| Globus pallidus principal cell | GABA | Large neuron of he globus pallidus, both internal and external segment, characterized by a large and fusiform or trangular cell soma with long, thick aspiny dendrites that may extend for over 1 mm. | Globus pallidus | ||
| Gracilis nucleus intrinsic cell | GABA | Gracile nucleus | |||
| Hippocampus CA1 ivy neuron | GABA | CA1 ivy cell ivy cell |
Ivy cells are highly abundant GABAergic interneurons when compared to basket, bistratified, or axo-axonic cells. "Ivy" cells are named after their dense and fine axons innervating mostly basal and oblique pyramidal cell dendrites. They express nitric oxide synthase, neuropeptide Y, and high levels of GABAa receptor aplha1 subunit and they are also identified as slow-spiking interneurons that regulate the excitability of pyramidal cell dendrites through slowly rising and decaying GABAergic inputs. | CA1 stratum pyramidale hippocampi | |
| Hippocampus CA1 oriens lacunosum moleculare neuron | GABA | CA1 O-LM interneuron | CA1 Oriens Lacunosum Moleculare (O-LM) cell is a neuron, which is characterized as a non-pyramidal cell type and interneuron that is mostly immunoreactive to GABAergic markers with the soma and dendrites mainly located in the CA1 stratum oriens and alveus, and axons extend directly to the stratum lacunosum-moleculare, ramifying there to form a dense plexus, forming symmetrical inhibitory synapses with the distal apical dendrites of pyramidal neurons while receiving excitatory input from CA1 recurrent collaterals in a disynaptic, feedback manner. | CA1 alveus CA1 stratum oriens |
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| Hippocampus CA2 basket cell broad | GABA | CA2 basket cell | The CA2 basket cells are the largest group of interneurons whose vertically oriented dendrites extend across all layers from stratum oriens into stratum lacunosum-moleculare and whose axons ramify extensively in stratum pyramidale. The broad basket cells have significantly broader dendritic width, and axonal arbors than that of other types of CA2 basket cells or of CA1 basket cells. | CA2 stratum pyramidale hippocampi | |
| Hippocampus CA2 basket cell narrow | GABA | CA2 basket cell | The CA2 basket cells are the largest group of interneurons in the CA2 region whose vertically oriented dendrites extend across all layers from stratum oriens into stratum lacunosum-moleculare and whose axons ramify extensively in stratum pyramidale. The narrow basket cells are narrow and both dendrites and axons are confined to the region of origin. | CA2 stratum pyramidale hippocampi | |
| Hippocampus CA2 bistratified cell broad | GABA | CA2 bistratified cell | The CA2 bistratified cells have radially oriented dendrites that resemble CA1 bistratified cells, but they extend through stratum oriens and stratum radiatum without entering stratum lacunosum-moleculare. The broad CA2 bistratified cells have dendrites that extend horizontally into all three CA subfields. | CA2 stratum pyramidale hippocampi | |
| Hippocampus CA2 bistratified cell narrow | GABA | CA2 bistratified cell | A type of neuron found in hippocampal area CA2 characterized by radially oriented dendrites that resemble CA1 bistratified cells, but they extend through stratum oriens and stratum radiatum without entering stratum lacunosum-moleculare. The narrow CA2 bistratified cell dendrites and axons are more confined within the CA2 region. | CA2 stratum pyramidale hippocampi | |
| Hippocampus CA3 IS-I cell | GABA | CA3 Interneuron-specific I cell | CA3 Interneuron Specific (IS) cells constitute IS-I, IS-II and IS-III based on their connectivity and neurochemical characteristics. IS-I neurons are visualized for CR and occur in all subfields of hippocampus and dentate gyrus. The CA3 IS-I cells has soma located in strata radiatum, oriens and pyramidale. The dendritic tree arborizes extensively in stratum radiatum but may also invade other layers. The characteristic feature of these dendrites is that they from long dendrodendritic junctions with each other. The main axons ramify in stratum radiatum, where they emit several collaterals that course in all directions. | CA3 alveus CA3 stratum oriens CA3 stratum radiatum CA3 stratum pyramidale hippocampi |
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| Hippocampus CA3 IS-II cell | GABA | CA3 interneuron-specific II cell | The CA3 IS-II cell type is visualized by immunostaining for VIP. IS-II neurons are characterized in hippocampus alone, where their somata are found in stratum radiatum. The dendritic tree consists of a tuft of smooth or sparsely spiny dendrites restricted to stratum lacunosum-moleculare, where they profusely arborize. The axon descends toward stratum pyramidale, thus forming weeping willowlike arbor. | CA3 stratum radiatum | |
| Hippocampus CA3 axo-axonic cell | GABA | CA3 chandelier cell | CA3 Chandelier cells of the hippocampus are very similar to those in the dentate gyrus. The cell bodies are located within or immediately adjacent to the pyramidal cell layer and possess radially oriented dendrites spanning all layers. According to the distribution of the dendritic tree, chandelier cells are in a position to receive excitatory input from all major sources of afferents in both the CA1 and CA3 subfields. | CA3 stratum pyramidale hippocampi | |
| Hippocampus CA3 basket cell | GABA | CA3 pyramidal basket cell | The CA3 basket cell is an interneuron located in hippocampus area CA3 characterized by a triangular or fusiform soma, with one to three dendrites extending from the cell soma. One of the three dendrites originate from the apical pole of soma, which then branch profusely, ascend through stratum radiatum, and often penetrate stratum lacunosum-moelculare. Primary basal dendrites are more numerous. They also branch close to soma and fan out toward the alveus, spanning the entire depth of stratum oriens. | CA3 stratum pyramidale hippocampi | |
| Hippocampus CA3 lacunosum moleculare neuron | GABA | CA3 LM interneurons | The CA3 Lacunosum Moleculare (LM) neurons are interneurons with somata in stratum lacunosum-moleculare that receive converging stimulation from the DG and entorhinal cortex as well as from within CA3. These LM neurons have dendrites that are oriented horizontally within the layer but occasionally have branches that extend into the pyramidal cell layer. The axon also takes a predominantly horizontal orientation and ramifies mainly in the stratum lacunosum-moleculare or superficial layer portion of the stratum radiatum. | CA3 stratum lacunosum moleculare | |
| Hippocampus CA3 oriens interneuron | GABA | CA3 SO interneuron CA3 SO neuron |
The CA3 stratum oriens interneuron is a fast spiking interneuron in hippocampal area CA3 with a main dendrite arborization extending in the stratum oriens and a widespread axonal arborization in all strata (Kawaguchi et al., 1987). The vast majority of dendritic processes were confined to the same layers as the cell bodies (Kantona et al., 1999). | CA3 alveus/oriens | |
| Hippocampus CA3 oriens lacunosum moleculare neuron | GABA | OLM cell | OLM cells (oriens/lacunosum-moleculare associated cell) has as its defining feature a dense axonal arbor that is confined to the stratum lacunosum-moleculare (also known as cells terminating in conjunction with entorhinal afferents). In principle the cell body and dendritic trees are located in the zones occupied by recurrent pyramidal cell collaterals. In CA3 this includes all strata except the stratum oriens. | CA3 stratum oriens CA3 alveus |
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| Hippocampus CA3 radiatum neuron | GABA | CA3 R interneuron | The CA3 Radiatum (R) neurons are interneurons with somata in stratum radiatum which receives converging stimulation from the DG and entorhinal cortex as well as from within CA3. The dendritic tree of R interneurons typically extend between the dorsal blade of the dentate gyrus and the stratum pyramidale of CA3. The axonal branches often extend beyond their layer of somatic residence into stratum lacunosum-moleculare or stratum pyramidale. | CA3 stratum radiatum | |
| Hippocampus CA3 spiny CR cell | GABA | CA3 Spiny CR immunoreactive cell CA3 Spiny CR-positive interneurons |
The CA3 spiny CR cell is an interneuron in Hippocampus that is present mostly in regions where mossy fibers have a high density, i.e., in the hilus of the dentate gyrus and in stratum lucidum of CA3 subfield. The dendrites and somata frequently possess numerous long hair-like spines that penetrate into bundles of mossy fibers. | CA3 stratum lucidum | |
| Hypoglossal nucleus GABA neuron | GABA | hypoglossal GABA neuron | Neuron in hypoglossal nucleus characterized by a small spindle shaped or fusiform soma | Hypoglossal nucleus | Macaca fuscata fuscata |
| Neostriatum GABA interneuron | GABA | GABA/parvalbumin striatal interneuron Gaba/parvalbumin interneuron neo striatum GABA interneuron neo striatum parvalbumin interneuron |
A type of interneuron located in the striatum that stain intensely for GABAergic markers and for parvalbumin. The cells are medium sized with round somata and smooth, sometimes varicose dendrites. THe axonal arborization banches extensively and often forms baskets on the somata of the spiny neurons. Intracellular staining studies suggest that these cells may be divided into two subgroups epending on whether their dendrites and axons ramify within 100-150 um of the soma or are more extended (up to 300 um) Adapted from Shepherd, G. M. The synaptic organization of the brain, 5th ed, New York: Oxford University Press. | Striatum | |
| Neostriatum SOM/NOS cell | GABA | striatal SOM/NOS interneuron SOM/NOS interneuron neostriatum SOM/NOS interneuron somatostatin/nitric oxide synthase interneuron |
Striatum | ||
| Neostriatum gaba/parvalbumin interneuron | GABA | GABA/parvalbumin striatal interneuron | A type of interneuron located in the striatum that stain intensely for GABAergic markers and for parvalbumin. The cells are medium sized with round somata and smooth, sometimes varicose dendrites. THe axonal arborization banches extensively and often forms baskets on the somata of the spiny neurons. Intracellular staining studies suggest that these cells may be divided into two subgroups epending on whether their dendrites and axons ramify within 100-150 um of the soma or are more extended (up to 300 um) Adapted from Shepherd, G. M. The synaptic organization of the brain, 5th ed, New York: Oxford University Press. | Striatum | |
| Neostriatum medium spiny neuron | GABA | Medium spiny neuron Neostriatal spiny neuron Medium-sized spiny neuron Striatal spiny neuron |
Striatum | Mammal | |
| Neostriatum parvalbumin interneuron | GABA | GABA/parvalbumin striatal interneuron | A type of interneuron located in the striatum that stain intensely for GABAergic markers and for parvalbumin. The cells are medium sized with round somata and smooth, sometimes varicose dendrites. THe axonal arborization banches extensively and often forms baskets on the somata of the spiny neurons. Intracellular staining studies suggest that these cells may be divided into two subgroups epending on whether their dendrites and axons ramify within 100-150 um of the soma or are more extended (up to 300 um) | Striatum | |
| Olfactory bulb (accessory) granule cell | GABA | Accessory olfactory bulb granule neuron Accessory olfactory bulb granule cell |
The main intrinsic neuron in the accessory olfactory bulb in the mammalian central nervous system. It resembles the granule cell in the main olfactory bulb, including the lack of an axon. Each cell gives rise to short central dendrites and a single long apical dendrite that traverses the granule cell layer, pierces the mitral cell body layer, and branches and terminates within the external plexiform layer among the lateral dendrites of mitral and tufted cells. The dendrites receive synaptic input from mitral and tufted cell dendrites, and have synaptic outputs to those dendrites through reciprocal dendrodendritic synapses. | Granule cell layer and within the mitral cell body layer. | Mammal |
| Olfactory bulb (main) Blanes cell | GABA | Blanes Cell Olfactory bulb (main) deep short axon cell short axon cell |
Large, stellate-shaped short-axon cell in the granule cell layer of the main olfactory bulb. | Granule cell layer of main olfactory bulb | Mammal |
| Olfactory bulb (main) granule cell | GABA | Granule cell of olfactory bulb Olfactory granule neuron |
The main intrinsic neuron in the vertebrate olfactory bulb. It lacks an axon. Each cell gives rise to short central dendrites and a single long apical dendrite that traverses the granule cell layer, pierces the mitral cell body layer, and branches and terminates within the external plexiform layer among the lateral dendrites of mitral and tufted cells. The dendrites receive synaptic input from mitral and tufted cell lateral dendrites, and have synaptic outputs on those dendrites through reciprocal dendrodendritic synapses. | Granule cell layer and within the mitral cell body layer. | Mammal |
| Olfactory bulb (main) periglomerular cell | GABA Dopamine |
Periglomerular neuron Olfactory bulb periglomerular cell |
Small intrinsic neuron in the glomerular layer of the olfactory bulb, with cell bodies surrounding the olfactory glomerulus. The cell body is 6-8 um in diameter, from which arises a short bushy dendrite that arborizes within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and engages in dendrodendritic interactions with mitral/tufted cell dendrites. Occasionally, bitufted PG cells connected to two glomeruli are seen. The axon distributes laterally within the extraglomerular region, extending as far as 5-10 glomeruli away. Some PG cells appear to lack axons. Subtypes may be identified based on their biochemical constituents. | Olfactory glomerular layer | Mammal |
| Olfactory cortex horizontal cell | GABA | Horizontal cell (olfactory) olfactory horizontal cell |
Large horizontally-elongated cell in layer I with smooth dendrites branching in layer Ia. | Piriform cortex layer I | Vertebrata |
| Olfactory cortex large multipolar cell | GABA | Olfactory cortex large multipolar neuron | A type of inhibitory intrinsic neuron found in the deep part of layer III of the olfactory cortex and the subjacent endopiriform nucleus. Several subpopulations of deep multipolar cells may be distinguished based on morphology, spiny/spsrsely spiny/aspiny, axon targets, and physiology. One subtype appears to be a basket cell targeted for pyramidal cell somata. | Olfactory cortex | Vertebrata |
| Olfactory cortex small globular cell | GABA | A small stellate cell with globular soma found in all layers of the piriform cortex. This cell is not clearly described in Neville and Haberly. | Olfactory cortex | ||
| Olfactory tubercle Islets of Calleja GABA cell | GABA | Islands of Calleja Gaba interneuron Islets of Calleja Gaba interneuron Olfactory tubercle Islets of Calleja GABA interneuron |
Olfactory tubercle | ||
| Striatum matrix medium spiny cell | GABA | Striatal matrix medium spiny cell | Striatal medium spiny cell that is located in the striatal matrix compartment | Striatal matrix compartment | Mammal |
| Substantia nigra pars reticulata interneuron GABA | GABA | substantia nigra pars reticulata GABA interneuron Substantia nigra pars reticulata GABA neuron Pars reticulata Gaba interneuron |
Substantia nigra pars reticulata | ||
| Substantia nigra pars reticulata principal cell | GABA | Substantia nigra pars reticulata principal neuron | Substantia nigra pars reticulata | ||
| Thalamic reticular nucleus cell | GABA | thalamic reticular cell Thalamic reticular nucleus neuron Thalamic reticular neuron |
Thalamic reticular nucleus | ||
| Thalamus interneuron small | GABA | Small interneuron thalamic small thalamic interneuron |
Thalamus | ||
| Tubermammillary nucleus large histamine neuron | Histamine GABA |
Tubermammillary histaminergic neuron | Large neuron in the tubermammillary nucleus that contains histamine and projects widely to the cerebral cortex characterized ultrastructurally by their large size, large spherical nucleus rarely indented, relatively large amounts of cytoplasm including well-developed perinuclearly organized golgi apparatus, numerous small mitochondria, clusters of small cisterns of the rough endoplasmic reticulum, the large emission cones of primary dendrites and by the partial wrapping by astroglia. | Tuberomammillary nucleus | Mammal |
