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Lambert-Eaton Myasthenic Syndrome
| Name: | Lambert-Eaton Myasthenic Syndrome |
| Definition: | An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve (MeSH). |
| Synonym(s): | Lambert-Eaton Syndrome, Myasthenic-Myopathic Syndrome of Eaton-Lambert, Eaton-Lambert Syndrome, Eaton-Lambert Myasthenic Syndrome, Myasthenic-Myopathic Syndrome of Lambert-Eaton |
| Super-category: | Neuromuscular Junction Diseases |
| Defining citation: | Adams et al., Principles of Neurology, 6th ed, pp 1471 |
| Id: | birnlex_12592 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
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| Created | 5 October 2007 + |
| CurationStatus | uncurated + |
| DefiningCitation | Adams et al., Principles of Neurology, 6th ed, pp 1471 + |
| Definition | An autoimmune disease characterized by wea … An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve (MeSH). sponse to stimulation of the nerve (MeSH). |
| DefinitionSource | MeSH + |
| Id | birnlex_12592 + |
| Label | Lambert-Eaton Myasthenic Syndrome + |
| ModifiedDate | 30 May 2009 + |
| Synonym | Lambert-Eaton Syndrome +, Myasthenic-Myopathic Syndrome of Eaton-Lambert +, Eaton-Lambert Syndrome +, Eaton-Lambert Myasthenic Syndrome +, and Myasthenic-Myopathic Syndrome of Lambert-Eaton + |