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Lambert-Eaton Myasthenic Syndrome

Name: Lambert-Eaton Myasthenic Syndrome
Definition: An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve (MeSH).
Synonym(s): Lambert-Eaton Syndrome, Myasthenic-Myopathic Syndrome of Eaton-Lambert, Eaton-Lambert Syndrome, Eaton-Lambert Myasthenic Syndrome, Myasthenic-Myopathic Syndrome of Lambert-Eaton
Super-category: Neuromuscular Junction Diseases
Defining citation: Adams et al., Principles of Neurology, 6th ed, pp 1471
Id: birnlex_12592
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Facts about Lambert-Eaton Myasthenic SyndromeRDF feed
Created5 October 2007  +
CurationStatusuncurated  +
DefiningCitationAdams et al., Principles of Neurology, 6th ed, pp 1471  +
DefinitionAn autoimmune disease characterized by wea An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve (MeSH). sponse to stimulation of the nerve (MeSH).
DefinitionSourceMeSH  +
Idbirnlex_12592  +
LabelLambert-Eaton Myasthenic Syndrome  +
ModifiedDate30 May 2009  +
SynonymLambert-Eaton Syndrome  +, Myasthenic-Myopathic Syndrome of Eaton-Lambert  +, Eaton-Lambert Syndrome  +, Eaton-Lambert Myasthenic Syndrome  +, and Myasthenic-Myopathic Syndrome of Lambert-Eaton  +
This page was last modified on 29 May 2009, at 11:32.This page has been accessed 195 times.