Category:Lambert-Eaton Myasthenic Syndrome

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Name: Lambert-Eaton Myasthenic Syndrome
Definition: An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve (MeSH).
Synonym(s): Lambert-Eaton Syndrome, Myasthenic-Myopathic Syndrome of Eaton-Lambert, Eaton-Lambert Syndrome, Eaton-Lambert Myasthenic Syndrome, Myasthenic-Myopathic Syndrome of Lambert-Eaton
Super-category: Neuromuscular Junction Diseases
Defining citation: Adams et al., Principles of Neurology, 6th ed, pp 1471
Id: birnlex_12592
Link to OWLRDF: Download this content as OWL/RDF


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