Category:Dentate gyrus IS-I cell
From NeuroLex
| Name: | Dentate gyrus IS-I cell |
| Definition: | The IS (Interneuron-Specific) subpopulation of interneurons have axons that exclusively innervate other interneurons. The Dentate gyrus IS-I class interneurons are visualized by immunostaining for Calretinin (CR) and establish multiple symmetrical synapses on the dendrites and somata of other CR-positive IS-I cells, Calbindin (CB) containing interneurons, and VIP-positive basket cells, but they do not innervate PV-containing interneurons. The dendrites of Dentate gyrus IS I neurons appear in all layers of Dentate gyrus and more characteristic feature of these dendrites is that they form long dendrodendritic junctions with each other. |
| Synonym(s): | DG Interneuron-specific cell |
| Abbreviation | DG IS-I |
| Super-category: | neuron |
| Defining citation: | p58 and p184. Andersen et al. "The Hippocampus Book" 2007; Freund & Buzsaki 1996 p374, PMID 8915675 |
| PMID: | PMID 8915675, PMID 17093119 |
| Id: | nlx_cell_091203 |
| Link to OWLRDF: | Download this content as OWL/RDF |
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| Soma Location: | Dentate gyrus molecular layer |
| Dendrite location: | Dentate gyrus molecular layer, Dentate gyrue granule cell layer, Hilus of dentate gyrus |
| Defining criteria: | long dendrodendritic junctions, in which typically two to three dendrites are intermingled for more than 100µm; extremely specific in innervating other interneurons |
| Location of axon arborization: | Dentate gyrus molecular layer, Dentate gyrus granule cell layer, Hilus of dentate gyrus |
| Neurotransmitter | GABA |
| Molecular constituents | Calretinin |
